Publications 2010-2016

Engineered mesenchymal stem cells as vectors in a suicide gene therapy against preclinical murine models for solid tumors. Amara I, Pramil E, Senamaud-Beaufort C, Devillers A, Macedo R, Lescaille G, Seguin J, Tartour E, Lemoine F, Beaune P, de Waziers I. J Control Release 2016; 239:82–91.

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide. Urbinati G, de Waziers I, Slamiç M, Foussignière T, Ali HM, Desmaële D, Couvreur P, Massaad-Massade L. Mol Ther Nucleic Acids. 2016 Mar 29;5:e301.

Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. Toselli F, de Waziers I, Dutheil M, Vincent M, Wilce PA, Dodd PR, Beaune P, Loriot MA, Gillam EM.Xenobiotica. 2015;45(12):1129-37. doi: 10.3109/00498254.2015.1040102. Epub 2015 Jun 22.

Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors. Amara I, Touati W, Beaune P, de Waziers I. Biochimie. 2014 Oct;105:4-11. doi: 10.1016/j.biochi.2014.06.016. Epub 2014 Jun 27. Review.

Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples. Al Ali A, Touboul D, Le Caër JP, Schmitz-Afonso I, Flinois JP, Marchetti C, de Waziers I, Brunelle A, Laprévote O, Beaune P. Anal Bioanal Chem. 2014 (in press)

Important Role of CYP2J2 in Protein Kinase Inhibitor Degradation: A Possible Role in Intratumor Drug Disposition and Resistance. Narjoz C, Favre A, McMullen J, Kiehl P, Montemurro M, Figg WD, Beaune P, de Waziers I, Rochat B. PLoS One. 2014, 9(5):e95532.

A Suicide Gene Therapy Combining the Improvement of Cyclophosphamide Tumor Cytotoxicity and the Development of an Anti-Tumor Immune Response. Touati W, Tran T, Seguin J, Diry M, Flinois JP, Baillou C, Lescaille G, Andre F, Tartour E, Lemoine FM, Beaune P, de Waziers I. Curr Gene Ther. 2014 (in press)

Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes. Ellero-Simatos S, Claus SP, Benelli C, Forest C, Letourneur F, Cagnard N, Beaune PH, de Waziers I. J Proteome Res. 2011 Dec 2;10(12):5493-502. doi: 10.1021/pr200765v.

Colonization-induced host-gut microbial metabolic interaction. Claus SP, Ellero SL, Berger B, Krause L, Bruttin A, Molina J, Paris A, Want EJ, de Waziers I, Cloarec O, Richards SE, Wang Y, Dumas ME, Ross A, Rezzi S, Kochhar S, Van Bladeren P, Lindon JC, Holmes E, Nicholson JK. MBio. 2011 Mar 1;2(2):e00271-10.

Could idiosyncratic thinking fit with << omics >>?. Narjoz C, Beaune P, de Waziers I. Med Sci (Paris). 2010 Jun-Jul;26(6-7):641-6. Review. French.

Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction. Ellero S, Chakhtoura G, Barreau C, Langouët S, Benelli C, Penicaud L, Beaune P, de Waziers I. Drug Metab Dispos. 2010 Apr;38(4):679-86.

Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells. Narjoz C, Marisa L, Imbeaud S, Paris A, Delacroix H, Beaune P, De Waziers I. Chem Res Toxicol. 2009 May;22(5):779-87.

Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottée L, Bièche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Declèves X, Duyckaerts C, Loriot MA. Drug Metab Dispos. 2009 Jul;37(7):1528-38.

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. Dauchy S, Dutheil F, Weaver RJ, Chassoux F, Daumas-Duport C, Couraud PO, Scherrmann JM, De Waziers I, Declèves X. J Neurochem. 2008 Dec;107(6):1518-28.

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Dauchy S, Miller F, Couraud PO, Weaver RJ, Weksler B, Romero IA, Scherrmann JM, De Waziers I, Declèves X. Biochem Pharmacol. 2009 Mar 1;77(5):897-909.

Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo. Nguyen TA, Tychopoulos M, Bichat F, Zimmermann C, Flinois JP, Diry M, Ahlberg E, Delaforge M, Corcos L, Beaune P, Dansette P, André F, de Waziers I. Mol Pharmacol. 2008 Apr;73(4):1122-33. Epub 2008 Jan 22. Erratum in: Mol Pharmacol. 2008 Jun;73(6):1866.

Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro. Valentová K, Truong NT, Moncion A, de Waziers I, Ulrichová J. J Agric Food Chem. 2007 Sep 19;55(19):7726-31.

Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Bièche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I. Pharmacogenet Genomics. 2007 Sep;17(9):731-42.

Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction. Girault I, Rougier N, Chesné C, Lidereau R, Beaune P, Bieche I, de Waziers I. Drug Metab Dispos. 2005 Dec;33(12):1803-10. Epub 2005 Aug 31.

A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein. Tychopoulos M, Corcos L, Genne P, Beaune P, de Waziers I. Cancer Gene Ther. 2005 May;12(5):497-508.

Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA. Truong NT, Moncion A, Barouki R, Beaune P, de Waziers I. Biochem J. 2005 May 15;388(Pt 1):227-35.

The activities of several detoxication enzymes are differentially induced by juices of garden cress, water cress and mustard in human HepG2 cells. Lhoste EF, Gloux K, De Waziers I, Garrido S, Lory S, Philippe C, Rabot S, Knasmüller S. Chem Biol Interact. 2004 Dec 7;150(3):211-9.

The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism. Valentová K, Moncion A, de Waziers I, Ulrichová J. Cell Biol Toxicol. 2004 Mar;20(2):109-20.

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices. Martin H, Sarsat JP, de Waziers I, Housset C, Balladur P, Beaune P, Albaladejo V, Lerche-Langrand C. Pharm Res. 2003 Apr;20(4):557-68.

Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin. Moncion A, Truong NT, Garrone A, Beaune P, Barouki R, De Waziers I. J Biol Chem. 2002 Nov 29;277(48):45904-10.

Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility. Stücker I, Hirvonen A, de Waziers I, Cabelguenne A, Mitrunen K, Cénée S, Koum-Besson E, Hémon D, Beaune P, Loriot MA. Carcinogenesis. 2002 Sep;23(9):1475-81.

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy. Cabelguenne A, Loriot MA, Stucker I, Blons H, Koum-Besson E, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P, De Waziers I. Int J Cancer. 2001 Sep 1;93(5):725-30.

Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population. Stücker I, Jacquet M, de Waziers I, Cénée S, Beaune P, Kremers P, Hémon D. Pharmacogenetics. 2000 Oct;10(7):617-27.

A repressive cross-regulation between catalytic and promoter activities of the CYP1A1 and CYP2E1 genes: role of H(2)O(2). Morel Y, de Waziers I, Barouki R. Mol Pharmacol. 2000 Jun;57(6):1158-64.

Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Simon T, Becquemont L, Mary-Krause M, de Waziers I, Beaune P, Funck-Brentano C, Jaillon P. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series. Cabelguenne A, Blons H, de Waziers I, Carnot F, Houllier AM, Soussi T, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P. J Clin Oncol. 2000 Apr;18(7):1465-73.

GSTM1, smoking and lung cancer: a case-control study. Stücker I, de Waziers I, Cenée S, Bignon J, Depierre A, Milleron B, Beaune P, Hémon D. Int J Epidemiol. 1999 Oct;28(5):829-35.

Human CYP2B6: expression, inducibility and catalytic activities. Gervot L, Rochat B, Gautier JC, Bohnenstengel F, Kroemer H, de Berardinis V, Martin H, Beaune P, de Waziers I. Pharmacogenetics. 1999 Jun;9(3):295-306.

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma. Blons H, Cabelguenne A, Carnot F, Laccourreye O, de Waziers I, Hamelin R, Brasnu D, Beaune P, Laurent-Puig P. Int J Cancer. 1999 Aug 20;84(4):410-5.

Detection and characterization of novel polymorphisms in the CYP2E1 gene. Fairbrother KS, Grove J, de Waziers I, Steimel DT, Day CP, Crespi CL, Daly AK. Pharmacogenetics. 1998 Dec;8(6):543-52.

Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. Eliasson E, Gardner I, Hume-Smith H, de Waziers I, Beaune P, Kenna JG. Chem Biol Interact. 1998 Nov 6;116(1-2):123-41.

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes. Gardner I, Wakazono H, Bergin P, de Waziers I, Beaune P, Kenna JG, Caldwell J. Carcinogenesis. 1997 Sep;18(9):1775-83.

The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide. Ploemen JP, Wormhoudt LW, Haenen GR, Oudshoorn MJ, Commandeur JN, Vermeulen NP, de Waziers I, Beaune PH, Watabe T, van Bladeren PJ. Toxicol Appl Pharmacol. 1997 Mar;143(1):56-69.

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines. Gervot L, Carrière V, Costet P, Cugnenc PH, Berger A, Beaune PH, de Waziers I. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):381-8.

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. Wormhoudt LW, Ploemen JH, de Waziers I, Commandeur JN, Beaune PH, van Bladeren PJ, Vermeulen NP. Chem Biol Interact. 1996 Sep 6;101(3):175-92.

Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells. Dubois M, Pfohl-Leszkowicz A, De Waziers I, Kremers P. Environ Toxicol Pharmacol. 1996 Jul 15;1(4):249-56.

Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. Carrière V, Berthou F, Baird S, Belloc C, Beaune P, de Waziers I. Pharmacogenetics. 1996 Jun;6(3):203-11.

Regulation of sucrase-isomaltase and hexose transporters in Caco-2 cells: a role for cytochrome P-4501A1? Carrière V, Barbat A, Rousset M, Brot-Laroche E, Dussaulx E, Cambier D, De Waziers ID, Beaune P, Zweibaum A. Am J Physiol. 1996 Jun;270(6 Pt 1):G976-86.

Rat liver epithelial cells express functional cytochrome P450 2E1. Lerche C, Le Jossic C, Fautrel A, de Waziers I, Ballet F, Guillouzo A, Corcos L. Carcinogenesis. 1996 May;17(5):1101-6.

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies. Belloc C, Baird S, Cosme J, Lecoeur S, Gautier JC, Challine D, de Waziers I, Flinois JP, Beaune PH. Toxicology. 1996 Jan 8;106(1-3):207-19.

P450 induction by Aroclor 1254 and 3,3',4,4'-tetrachlorobiphenyl in cultured hepatocytes from rat, quail and man: interspecies comparison. Dubois M, De Waziers I, Thome JP, Kremers P. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Jan;113(1):51-9.

High levels of DNA adducts in human colon are associated with colorectal cancer. Pfohl-Leszkowicz A, Grosse Y, Carrière V, Cugnenc PH, Berger A, Carnot F, Beaune P, de Waziers I. Cancer Res. 1995 Dec 1;55(23):5611-6.

Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line. De Waziers I, Garlatti M, Bouguet J, Beaune PH, Barouki R. Mol Pharmacol. 1995 Mar;47(3):474-9.

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7. Carrière V, Lesuffleur T, Barbat A, Rousset M, Dussaulx E, Costet P, de Waziers I, Beaune P, Zweibaum A. FEBS Lett. 1994 Dec 5;355(3):247-50. Erratum in: FEBS Lett 1995 Mar 27;362(1):99.

Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides. Haber D, Siess MH, de Waziers I, Beaune P, Suschetet M. Xenobiotica. 1994 Feb;24(2):169-82.

Presence of proteins recognized by mammalian cytochrome P-450 antibodies in Euglena gracilis. Briand J, Julistiono H, Beaune P, Flinois JP, de Waziers I, Leroux JP. Biochim Biophys Acta. 1993 Dec 8;1203(2):199-204.

Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma. Janot F, Massaad L, Ribrag V, de Waziers I, Beaune PH, Luboinski B, Parise O Jr, Gouyette A, Chabot GG. Carcinogenesis. 1993 Jul;14(7):1279-83.

Screening of principal enzymes involved in the metabolism of anticancer drugs in human and murine colonic tumors. Massaad L, de Waziers I, Ribrag V, Janot F, Morizet J, Beaune PH, Gouyette A, Chabot GG. Bull Cancer. 1993 May;80(5):397-407. French.

Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems. Massaad L, de Waziers I, Ribrag V, Janot F, Beaune PH, Morizet J, Gouyette A, Chabot GG. Cancer Res. 1992 Dec 1;52(23):6567-75.

Cytochrome P450 induction and mutagenicity of 2-aminoanthracene (2AA) in rat liver and gut. Carrière V, de Waziers I, Courtois YA, Leroux JP, Beaune PH. Mutat Res. 1992 Jul;268(1):11-20.

Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data. Flinois JP, Chabin M, Egros F, Dufour A, de Waziers I, Mas-Chamberlin C, Beaune PH. J Pharmacol Exp Ther. 1992 Apr;261(1):381-6.

Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao). de Waziers I, Bouguet J, Beaune PH, Gonzalez FJ, Ketterer B, Barouki R. Pharmacogenetics. 1992 Feb;2(1):12-8.

Effects of ethanol and clofibrate on expression of cytochrome P-450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes. Perrot N, Chesné C, De Waziers I, Conner J, Beaune PH, Guillouzo A. Eur J Biochem. 1991 Aug 15;200(1):255-61.

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples. de Waziers I, Cugnenc PH, Berger A, Leroux JP, Beaune PH. Carcinogenesis. 1991 May;12(5):905-9.

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. de Waziers I, Cugnenc PH, Yang CS, Leroux JP, Beaune PH. J Pharmacol Exp Ther. 1990 Apr;253(1):387-94.

Pre- and postweaning development of drug-metabolizing enzyme activities in small intestine and liver of rats. de Waziers I, Boisset M, Atteba S. Drug Metab Dispos. 1988 Mar-Apr;16(2):310-5.

Drug-metabolizing enzyme activities in the liver and intestine of rats exposed to DDT: effects of vitamin A status. de Waziers I, Azaïs V. Arch Environ Contam Toxicol. 1987 May;16(3):343-8.

The effects of vitamin A nutritional status on glutathione, glutathione transferase and glutathione peroxidase activities in rat intestine. de Waziers I, Albrecht R. Experientia. 1987 Apr 15;43(4):394-5.

Genotype identification of 10-day old Zucker rats by lipid content of inguinal fat pad. de Waziers I, Planche E, Joliff M. Int J Obes. 1985;9(1):21-4.

Effects of insulin in vitro on lipogenesis and fatty acid uptake in white adipose tissue of Zucker rats aged 10 days. de Waziers I, Planche E. Biochem J. 1984 Mar 1;218(2):653-5.

Effect of glutathione and uridine-5'-diphosphoglucuronic acid on the mutagenicity of tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by rat-liver and -intestine S9 fraction. de Waziers I, Decloître F. Mutat Res. 1984 Jan;139(1):15-9.

In vitro study on lipogenesis and exogeneous fatty acid uptake in white adipose tissue of lean and obese Zucker rats aged 10 days. de Waziers I, Planche E. Horm Metab Res. 1983 Nov;15(11):564-5.

Formation of mutagenic derivatives from tryptophan pyrolysis products (Trp P1 and Trp P2) by rat intestinal S9 fraction. de Waziers I, Decloitre F. Mutat Res. 1983 Feb;119(2):103-8.