Arnaud Cachia (Prof.)

Arnaud Cachia

Arnaud Cachia

I am full Professor in Integrative Neurosciences at Paris Descartes University and member of the Institut Universitaire de France (IUF). My research aims at deciphering the neurodevelopmental bases of cognition. I am interested in the early stage of brain development during fetal life and its long-term effects on cognition. These early constraints on cognitive variability and development are less known than the neuroplasticity mechanisms, extensively investigated these last years. In this context, I investigated the associations between variations of cortex sulcation - a stable feature of brain anatomy determined in utero - and clinical symptoms in neurodevelopmental psychiatric and neurogenetic disorders. Using the same brain imaging methods and the same theoretical framework, I have recently started to study the neurodevelopmental bases of normal variability and development of cognitive control in typically developing children.

See details on my personal web page.

Contact: arnaud.cachia@parisdescartes.fr

Publications

Journal articles

2015

Aiello, M., Salvatore, E., Cachia, A., Pappatà, S., Cavaliere, C., Prinster, A., Nicolai, E., Salvatore, M., Baron, J.C., & Quarantelli, M (2015). Relationship between simultaneously acquired resting-state regional cerebral glucose metabolism and functional MRI: A PET/MR hybrid scanner study.  NeuroImage, 113, 111-121.

Bourgin, J., Cachia, A., Boumezbeur, F., Djemaï, B., Bottlaender, M., Duchesnay, E., Mériaux, S., & Jay, T.M. (2015). Hyper-responsivity to stress in rats is associated with a large increase in amygdala volume. A 7 T MRI study. European Neuropsychopharmacology, 25, 828-835.

Cachia, A., Amad, A., Brunelin, J., Krebs, M.O., Plaze, M., Thomas, P., & Jardri, R. (2015). Deviations in cortex sulcation associated with visual hallucinations in schizophrenia. Molecular Psychiatry, 20, 1101-1107.

Mellerio, C., Roca, P., Chassoux, F., Danière, F., Cachia, A.,  Naggara, O., Devaux, B., Meder, J.-F., & Oppenheim, C. (2015). The "Power Button Sign”: a New Central Sulcal Pattern on Surface Rendering MRI of Type 2 Focal Cortical Dysplasia. Radiology, 274, 500-507.

Roca, P., Mellerio, C., Chassoux, F., Rivière, D, Cachia, A., Charron, S., Lion, S., Mangin, J.F., Devaux, B., Meder, J.F., & Oppenheim, C. (2015). Sulcus-based MR analysis of focal cortical dysplasia located in the central region. PLoS One, 10(3):e0122252. doi: 10.1371/journal.pone.0122252.

2014

Amad, A., Cachia, A., Gorwood, P., Pins, D., Delmaire, C., Rolland, B., Mondino, M., Thomas, P., & Jardri, R. (2014). The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations. Molecular Psychiatry, 19, 184-191.

Borst, G., Cachia, A., Vidal., J., Simon, G., Fischer, C., Pineau, A., Poirel, N., Mangin, J.-F., & Houdé, O. (2014). Folding of the anterior cingulate cortex partially explains inhibitory control during childhood: A longitudinal study. Developmental Cognitive Neuroscience, 9, 126-135.

Cachia, A.*, Borst, G.*, Vidal, J., Fischer, C., Pineau, A., Mangin, J.-F., & Houdé, O. (2014). The shape of the anterior cingulate cortex contributes to cognitive control efficiency in preschoolers. Journal of Cognitive Neuroscience, 26, 96-106.

Dickie, E.W., Tahmasebi, A., French, L., Kovacevic, N., Banaschewski, T., Barker, G.J., Bokde, A., Büchel, C., Conrod, P., Flor, H., Garavan, H., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., Mann, K., Martinot, J.L., Nees, F., Nichols, T., Lathrop, M., Loth, E., Pausova, Z., Rietschel, M., Smolka, M.N., Ströhle, A., Toro, R., Schumann, G., Paus, T., & IMAGEN consortium. (2014). Global genetic variations predict brain response to faces. PLoS Genetics,10(8):e1004523. doi: 10.1371/journal.pgen.1004523.

2013

Gay, O., Plaze, M., Oppenheim, C., Mouchet-Mages, S., Gaillard, R., Olié, J.-P., Krebs, M.-O., & Cachia, A. (2013). Cortex morphology in first episode psychosis patients with neurological soft signs. Schizophrenia Bulletin, 39, 820-829.

Rossi, S., Lubin, A., Simon, G., Lanoë, C., Poirel, N., Cachia, A., Pineau, A., & Houdé, O. (2013). Structural brain correlates of executive engagement in working memory: Children's inter-individual differences are reflected in the anterior insular cortex. Neuropsychologia, 51, 1145-1150.

2012

Allen, P., Modinos, G., Hubl, D., Shields, G., Cachia, A., Jardri, R., Thomas, P., Woodward, T., Shotbolt, P., Plaze, M., & Hoffman, R. (2012). Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond. Schizophrenia Bulletin, 38(4), 695-703.

Lippé, S., Poupon, C., Cachia, A., Archambaud, F., Rodrigo, S., Dorfmuller, G., Chiron, C., Hertz-Pannier, L. (2012). White matter abnormalities revealed by DTI correlate with interictal grey matter FDG-PET metabolism in focal childhood epilepsies. Epileptic Disorders, 14(4), 404-413.

Stacey, D., Bilbao, A., Maroteaux, M., Jia, T., Easton, A.C., Longueville, S., Nymberg, C., Banaschewski, T., Barker, G.J., Büchel, C., Carvalho, F., Conrod, P.J., Desrivières, S., Fauth-Bühler, M., Fernandez-Medarde, A., Flor, H., Gallinat, J., Garavan, H., Bokde, A.L., Heinz, A., Ittermann, B., Lathrop, M., Lawrence, C., Loth, E., Lourdusamy, A., Mann, K.F., Martinot, J.L., Nees, F., Palkovits, M., Paus, T., Pausova, Z., Rietschel, M., Ruggeri, B., Santos, E., Smolka, M.N., Staehlin, O., Jarvelin, M.R., Elliott, P., Sommer, W.H., Mameli, M., Müller, C.P., Spanagel, R., Girault, J.A., Schumann, G., & IMAGEN Consortium. (2012). RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proceedings of the National Academy of Sciences of the United States of America, 18;109(51):21128-33.

2011

Duchesnay, E., Cachia, A., Boddaert, N., Chabane, N., Mangin, J.-F., Martinot, J.-L., Brunelle, F., & Zilbovicius, M. (2011). Feature selection and classification of imbalanced datasets: application to PET images of children with autistic spectrum disorders. Neuroimage, 57(3), 1003-1014.

Mouchet Mages, S., Rodrigo, S., Cachia, A., Faycal, M., Olié, J.-P., Meder, J.-F., Oppenheim, C., & Krebs, M.-O. (2011). Correlations of cerebello-thalamo-prefrontal structure ans neurological soft-signs in patients with first episode psychosis. Acta Psychatrica Scandinavica, 123(6), 451-458.

Plaze, M., Paillère-Martinot, M.-L., Penttilä, J., Januel, D., de Beaurepaire, R., Bellivier, F., Andoh, J., Galinowski, A., Artiges, E., Olié, J.-P., Mangin, J.-F., Martinot, J.-L., & Cachia, A. (2011). “Where do auditory hallucinations come from?” - A brain morphometry study of schizophrenia patients with inner or outer space hallucinations. Schizophrenia Bulletin, 37(1), 212-221. 

2010

Mangin, J.-F., Jouvent, E., & Cachia, A. (2010).  In vivo measurement of cortical morphology: means and meanings. Current Opinion in Neurology, 23(4), 359-367.

2009

Andoh, J., Riviere, D., Mangin, J.-F., Artiges, E., Cointepas, Y., Paillère-Martinot, M.-L., Martinot, J.-L., & Cachia, A. (2009). A low-cost MRI-guided method for TMS coil positioning. Brain Stimulation, 2(3), 123-131.

Penttilä, J., Cachia, A., Martinot, J.-L., Ringuenet, D., Wessa, M., Houenou, J., Galinowski, A., Bellivier, F., Gallarda, T., Duchesnay, E., Artiges, E., Leboyer, M., Olié, J.-P., Mangin, J.-F., & Paillère-Martinot, M.-L. (2009). Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder. Bipolar Disorder, 11(4), 361-370.

Penttilä, J., Paillère-Martinot, M.-L., Martinot, J.-L., Ringuenet, D., Galinowski, A., Houenou, J., Bellivier, F., Wessa, M., Artiges, E., Gallarda, T., Bruguière, P., Pinabel, F., Leboyer, M., Olié, J.-P., Duchesnay, E., Mangin, J.-F., & Cachia, A. (2009). Cortical folding in treatment-resistant depression. Journal of Psychiatry & Neuroscience, 34(2), 127-135.

2008

Dubois, J., Benders, M., Borradori-Tolsa, C., Cachia, A., Lazeyras, F., Ha-Vinh Leuchter, R., Sizonenko, S.V., Mangin, J.-F., & Hüppi, P.S. (2008). Primary cortical folding in the human newborn: an early marker of later functional development. Brain, 131(Pt 8), 2028-2041. 

Dubois, J., Hertz-Pannier, L., Cachia, A. , Mangin, J.-F., Le Bihan, D., & Dehaene-Lambertz, G. (2008). Structural asymmetries in the infant language and sensori-motor networks. Cerebral Cortex, 19(2), 414-423.

Cachia, A., Paillère-Martinot, M.-L., Galinowski, A., Januel, D., de Beaurepaire, R., Bellivier, F., Artiges, E., Andoh, J., Bartrés-Faz, D., Duchesnay, E., Rivière, D., Plaze, M., Mangin, J.-F., & Martinot, J.-L. (2008). Cortical folding abnormalities in schizophrenia patients with resistant auditory hallucinations. Neuroimage, 39(3), 927-935.

Chanraud, S., Reynaud, M., Wessa, M., Penttilä, J., Kostogianni, N., Cachia, A., Artiges, E., Delain, F., Perrin, M., Aubin, H.-J., Cointepas, Y., Martelli, C., & Martinot, J.-L. (2008). Diffusion tensor tractography in mesencephalic bundles: relation to mental flexibility in detoxified alcohol-dependent subjects. Neuropsychopharmacology, 34(5), 1223-1232.

Penttilä, J., Paillère-Martinot, M.-L., Martinot, J.-L., Mangin, J.-F., Frangou, S., & Cachia, A. (2008). Cortical Folding in Adolescent-onset Schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 47(10), 1125-1133.

Perrin, M., Cointepas, Y., Cachia, A., Poupon, C., Thirion, B., Rivière, D., Cathier, P., El Kouby, V., Constantinesco, A., Le Bihan, D., & Mangin, J.-F. (2008). Connectivity-based parcellation of the cortical mantle using q-ball diffusion imaging. International Journal of Biomedical Imaging, Article ID 368406.

2007

Dubois, J., Benders, M., Cachia, A., Lazeyras, F., Ha-Vinh Leuchter, R., Sizonenko, S.V., Borradori-Tolsa, C., Mangin, J.-F., & Hüppi, P.S. (2007). Mapping the early cortical folding process in the preterm newborn brain. Cerebral Cortex, 18(6), 1444-1454.

Duchesnay, E., Cachia, A., Roche, A., Rivière, D., Cointepas, Y., Papadopoulos-Orfanos, D., Zilbovicius, M., Martinot, J.-L., Régis, J., & Mangin, J-F. (2007). Classification from cortical folding patterns. IEEE Transactions on Medical Imaging, 26(4), 553-565.

Mouchet-Mages, S., Cachia, A., Canceil, O., Rodrigo, S., Oppenheim, C., Willard, D., Meder, J.-F., Martinot, J.-L., & Krebs, M.-O. (2007). Sensory dysfunction is correlated to cerebellar volume reduction in early schizophrenia. Schizophrenia Research, 91(1-3), 266-269.

2006

Boddaert, N., Mochel, F., Meresse, I., Seidenwurm, D., Cachia, A., Brunelle, F., Lyonnet, S., & Zilbovicius, M. (2006). Parieto-occipital grey matter abnormalities in children with Williams syndrome. Neuroimage, 30(3), 721-725.

2005

Andoh, J., Artiges, E., Pallier, C., Rivière, D., Mangin, J.-F., Cachia, A., Plaze, M., Paillère-Martinot, M.-L., & Martinot, J.-L. (2005). Modulation of language areas with functional MR image-guided magnetic stimulation. Neuroimage, 29(2), 619-627.

Régis, J., Mangin, J.-F., Ochiai, T., Frouin, V., Rivière, D., Cachia, A. , Tamura, M., & Samson, Y. (2005). Sulcal root generic model: a hypothesis to overcome the variability of the human cortex folding patterns. Neurologia Medico Chirurgica, 45, 1-17.

2004

Mangin, J.-F., Poupon, F., Duchesnay, E., Rivière, D., Cachia, A., Collins, D.L., Evans, A.C., & Régis, J. (2004). Brain Morphometry using 3D Moment Invariants. Medical Image Analysis, 8, 187-196.

Mangin, J.-F., Rivière, D., Cachia, A., Duchesnay, E., Cointepas, Y., Papadopoulos-Orfanos, D., Collins, D.L., Evans, A.C., & Régis, J. (2004). Object-based morphometry of the cerebral cortex. IEEE Transactions on Medical Imaging, 23(8), 968-982.

Mangin, J.-F., Rivière, D., Cachia, A., Duchesnay, E., Cointepas, Y., Papadopoulos-Orfanos, D., Scifo, P., Ochiai, T., Brunelle, F., & Régis, J. (2004). A framework to study the cortical folding patterns. Neuroimage, 23, S129-S138.

Mangin, J.-F., Rivière, D., Coulon, O., Poupon, C., Cachia, A., Cointepas, Y., Poline, J.-B., Le Bihan, D., Régis, J., & Papadopoulos-Orfanos, D. (2004). Coordinate-based versus structural approaches to brain image analysis. Artificial Intelligence in Medicine, 30, 177-197.

Molko, N., Cachia, A., Rivière, D., Mangin, J.-F., Bruandet, M, Le Bihan, D., Cohen, L., & Dehaene, S. (2004). Brain Anatomy in Turner Syndrome: Evidence for Impaired Social and Spatial-Numerical Networks. Cerebral Cortex, 14(8), 840-850.

2003

Cachia, A., Mangin, J.-F., Rivière, D., Kherif, F., Boddaert, N., Andrade, A., Papadopoulos-Orfanos, D., Poline, J.-B., Bloch, I., Zilbovicius, M., Sonigo, P., Brunelle, F., & Régis, J. (2003). A Primal Sketch of the Cortex Mean Curvature: a Morphogenesis Based Approach to Study the Variability of the Folding Patterns. IEEE Transactions on Medical Imaging, 22(6), 754-765.

Cachia, A., Mangin, J.-F., Rivière, D., Papadopoulos-Orfanos, D., Kherif, F., Bloch, I., & Régis, J. (2003). A generic framework for parcellation of the cortical surface into gyri using geodesic Voronoï diagrams. Medical Image Analysis, 7(4), 403-416.

Molko, N., Cachia, A., Rivière, D., Mangin, J.-F., Bruandet, M., Le Bihan, D., Cohen, L., & Dehaene, S. (2003). Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin. Neuron, 40, 847-858.

Book

Jardri, R., Cachia, A., Thomas, P. & Pins, D. (Editors). The Neuroscience of Hallucinations. Springer-Verlag New York Inc. Sept. 2012. web

Jardri, R., Pins, D., Thomas, P., & Cachia, A. Key-issues for future research in the neuroscience of hallucinations. The Neuroscience of hallucinations (Ed. R. Jardri, A. Cachia, D. Pins, P. Thomas). Springer US.

Plaze, M., & Cachia, A. Structural imaging of the ‘hallucinating’ brain in schizophrenia. The Neuroscience of hallucinations (Ed. R. Jardri, A. Cachia, D. Pins, P. Thomas). Springer US.