Arnaud Cachia (Prof.)

Arnaud Cachia

Arnaud Cachia

I am full Professor in Integrative Neurosciences at Paris Descartes University and member of the Institut Universitaire de France (IUF). My research aims at deciphering the neurodevelopmental bases of cognition. I am interested in the early stage of brain development during fetal life and its long-term effects on cognition. These early constraints on cognitive variability and development are less known than the neuroplasticity mechanisms, extensively investigated these last years. In this context, I investigated the associations between variations of cortex sulcation - a stable feature of brain anatomy determined in utero - and clinical symptoms in neurodevelopmental psychiatric and neurogenetic disorders. Using the same brain imaging methods and the same theoretical framework, I have recently started to study the neurodevelopmental bases of normal variability and development of cognitive control in typically developing children.

See details on my personal web page.



Journal articles


Aiello, M., Salvatore, E., Cachia, A., Pappatà, S., Cavaliere, C., Prinster, A., Nicolai, E., Salvatore, M., Baron, J.C., & Quarantelli, M (2015). Relationship between simultaneously acquired resting-state regional cerebral glucose metabolism and functional MRI: A PET/MR hybrid scanner study.  NeuroImage, 113, 111-121.

Bourgin, J., Cachia, A., Boumezbeur, F., Djemaï, B., Bottlaender, M., Duchesnay, E., Mériaux, S., & Jay, T.M. (2015). Hyper-responsivity to stress in rats is associated with a large increase in amygdala volume. A 7 T MRI study. European Neuropsychopharmacology, 25, 828-835.

Cachia, A., Amad, A., Brunelin, J., Krebs, M.O., Plaze, M., Thomas, P., & Jardri, R. (2015). Deviations in cortex sulcation associated with visual hallucinations in schizophrenia. Molecular Psychiatry, 20, 1101-1107.

Mellerio, C., Roca, P., Chassoux, F., Danière, F., Cachia, A.,  Naggara, O., Devaux, B., Meder, J.-F., & Oppenheim, C. (2015). The "Power Button Sign”: a New Central Sulcal Pattern on Surface Rendering MRI of Type 2 Focal Cortical Dysplasia. Radiology, 274, 500-507.

Roca, P., Mellerio, C., Chassoux, F., Rivière, D, Cachia, A., Charron, S., Lion, S., Mangin, J.F., Devaux, B., Meder, J.F., & Oppenheim, C. (2015). Sulcus-based MR analysis of focal cortical dysplasia located in the central region. PLoS One, 10(3):e0122252. doi: 10.1371/journal.pone.0122252.


Amad, A., Cachia, A., Gorwood, P., Pins, D., Delmaire, C., Rolland, B., Mondino, M., Thomas, P., & Jardri, R. (2014). The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations. Molecular Psychiatry, 19, 184-191.

Borst, G., Cachia, A., Vidal., J., Simon, G., Fischer, C., Pineau, A., Poirel, N., Mangin, J.-F., & Houdé, O. (2014). Folding of the anterior cingulate cortex partially explains inhibitory control during childhood: A longitudinal study. Developmental Cognitive Neuroscience, 9, 126-135.

Cachia, A.*, Borst, G.*, Vidal, J., Fischer, C., Pineau, A., Mangin, J.-F., & Houdé, O. (2014). The shape of the anterior cingulate cortex contributes to cognitive control efficiency in preschoolers. Journal of Cognitive Neuroscience, 26, 96-106.

Dickie, E.W., Tahmasebi, A., French, L., Kovacevic, N., Banaschewski, T., Barker, G.J., Bokde, A., Büchel, C., Conrod, P., Flor, H., Garavan, H., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., Mann, K., Martinot, J.L., Nees, F., Nichols, T., Lathrop, M., Loth, E., Pausova, Z., Rietschel, M., Smolka, M.N., Ströhle, A., Toro, R., Schumann, G., Paus, T., & IMAGEN consortium. (2014). Global genetic variations predict brain response to faces. PLoS Genetics,10(8):e1004523. doi: 10.1371/journal.pgen.1004523.


Gay, O., Plaze, M., Oppenheim, C., Mouchet-Mages, S., Gaillard, R., Olié, J.-P., Krebs, M.-O., & Cachia, A. (2013). Cortex morphology in first episode psychosis patients with neurological soft signs. Schizophrenia Bulletin, 39, 820-829.

Rossi, S., Lubin, A., Simon, G., Lanoë, C., Poirel, N., Cachia, A., Pineau, A., & Houdé, O. (2013). Structural brain correlates of executive engagement in working memory: Children's inter-individual differences are reflected in the anterior insular cortex. Neuropsychologia, 51, 1145-1150.


Allen, P., Modinos, G., Hubl, D., Shields, G., Cachia, A., Jardri, R., Thomas, P., Woodward, T., Shotbolt, P., Plaze, M., & Hoffman, R. (2012). Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond. Schizophrenia Bulletin, 38(4), 695-703.

Lippé, S., Poupon, C., Cachia, A., Archambaud, F., Rodrigo, S., Dorfmuller, G., Chiron, C., Hertz-Pannier, L. (2012). White matter abnormalities revealed by DTI correlate with interictal grey matter FDG-PET metabolism in focal childhood epilepsies. Epileptic Disorders, 14(4), 404-413.

Stacey, D., Bilbao, A., Maroteaux, M., Jia, T., Easton, A.C., Longueville, S., Nymberg, C., Banaschewski, T., Barker, G.J., Büchel, C., Carvalho, F., Conrod, P.J., Desrivières, S., Fauth-Bühler, M., Fernandez-Medarde, A., Flor, H., Gallinat, J., Garavan, H., Bokde, A.L., Heinz, A., Ittermann, B., Lathrop, M., Lawrence, C., Loth, E., Lourdusamy, A., Mann, K.F., Martinot, J.L., Nees, F., Palkovits, M., Paus, T., Pausova, Z., Rietschel, M., Ruggeri, B., Santos, E., Smolka, M.N., Staehlin, O., Jarvelin, M.R., Elliott, P., Sommer, W.H., Mameli, M., Müller, C.P., Spanagel, R., Girault, J.A., Schumann, G., & IMAGEN Consortium. (2012). RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proceedings of the National Academy of Sciences of the United States of America, 18;109(51):21128-33.


Duchesnay, E., Cachia, A., Boddaert, N., Chabane, N., Mangin, J.-F., Martinot, J.-L., Brunelle, F., & Zilbovicius, M. (2011). Feature selection and classification of imbalanced datasets: application to PET images of children with autistic spectrum disorders. Neuroimage, 57(3), 1003-1014.

Mouchet Mages, S., Rodrigo, S., Cachia, A., Faycal, M., Olié, J.-P., Meder, J.-F., Oppenheim, C., & Krebs, M.-O. (2011). Correlations of cerebello-thalamo-prefrontal structure ans neurological soft-signs in patients with first episode psychosis. Acta Psychatrica Scandinavica, 123(6), 451-458.

Plaze, M., Paillère-Martinot, M.-L., Penttilä, J., Januel, D., de Beaurepaire, R., Bellivier, F., Andoh, J., Galinowski, A., Artiges, E., Olié, J.-P., Mangin, J.-F., Martinot, J.-L., & Cachia, A. (2011). “Where do auditory hallucinations come from?” - A brain morphometry study of schizophrenia patients with inner or outer space hallucinations. Schizophrenia Bulletin, 37(1), 212-221. 


Mangin, J.-F., Jouvent, E., & Cachia, A. (2010).  In vivo measurement of cortical morphology: means and meanings. Current Opinion in Neurology, 23(4), 359-367.


Andoh, J., Riviere, D., Mangin, J.-F., Artiges, E., Cointepas, Y., Paillère-Martinot, M.-L., Martinot, J.-L., & Cachia, A. (2009). A low-cost MRI-guided method for TMS coil positioning. Brain Stimulation, 2(3), 123-131.

Penttilä, J., Cachia, A., Martinot, J.-L., Ringuenet, D., Wessa, M., Houenou, J., Galinowski, A., Bellivier, F., Gallarda, T., Duchesnay, E., Artiges, E., Leboyer, M., Olié, J.-P., Mangin, J.-F., & Paillère-Martinot, M.-L. (2009). Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder. Bipolar Disorder, 11(4), 361-370.

Penttilä, J., Paillère-Martinot, M.-L., Martinot, J.-L., Ringuenet, D., Galinowski, A., Houenou, J., Bellivier, F., Wessa, M., Artiges, E., Gallarda, T., Bruguière, P., Pinabel, F., Leboyer, M., Olié, J.-P., Duchesnay, E., Mangin, J.-F., & Cachia, A. (2009). Cortical folding in treatment-resistant depression. Journal of Psychiatry & Neuroscience, 34(2), 127-135.


Dubois, J., Benders, M., Borradori-Tolsa, C., Cachia, A., Lazeyras, F., Ha-Vinh Leuchter, R., Sizonenko, S.V., Mangin, J.-F., & Hüppi, P.S. (2008). Primary cortical folding in the human newborn: an early marker of later functional development. Brain, 131(Pt 8), 2028-2041. 

Dubois, J., Hertz-Pannier, L., Cachia, A. , Mangin, J.-F., Le Bihan, D., & Dehaene-Lambertz, G. (2008). Structural asymmetries in the infant language and sensori-motor networks. Cerebral Cortex, 19(2), 414-423.

Cachia, A., Paillère-Martinot, M.-L., Galinowski, A., Januel, D., de Beaurepaire, R., Bellivier, F., Artiges, E., Andoh, J., Bartrés-Faz, D., Duchesnay, E., Rivière, D., Plaze, M., Mangin, J.-F., & Martinot, J.-L. (2008). Cortical folding abnormalities in schizophrenia patients with resistant auditory hallucinations. Neuroimage, 39(3), 927-935.

Chanraud, S., Reynaud, M., Wessa, M., Penttilä, J., Kostogianni, N., Cachia, A., Artiges, E., Delain, F., Perrin, M., Aubin, H.-J., Cointepas, Y., Martelli, C., & Martinot, J.-L. (2008). Diffusion tensor tractography in mesencephalic bundles: relation to mental flexibility in detoxified alcohol-dependent subjects. Neuropsychopharmacology, 34(5), 1223-1232.

Penttilä, J., Paillère-Martinot, M.-L., Martinot, J.-L., Mangin, J.-F., Frangou, S., & Cachia, A. (2008). Cortical Folding in Adolescent-onset Schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 47(10), 1125-1133.

Perrin, M., Cointepas, Y., Cachia, A., Poupon, C., Thirion, B., Rivière, D., Cathier, P., El Kouby, V., Constantinesco, A., Le Bihan, D., & Mangin, J.-F. (2008). Connectivity-based parcellation of the cortical mantle using q-ball diffusion imaging. International Journal of Biomedical Imaging, Article ID 368406.


Dubois, J., Benders, M., Cachia, A., Lazeyras, F., Ha-Vinh Leuchter, R., Sizonenko, S.V., Borradori-Tolsa, C., Mangin, J.-F., & Hüppi, P.S. (2007). Mapping the early cortical folding process in the preterm newborn brain. Cerebral Cortex, 18(6), 1444-1454.

Duchesnay, E., Cachia, A., Roche, A., Rivière, D., Cointepas, Y., Papadopoulos-Orfanos, D., Zilbovicius, M., Martinot, J.-L., Régis, J., & Mangin, J-F. (2007). Classification from cortical folding patterns. IEEE Transactions on Medical Imaging, 26(4), 553-565.

Mouchet-Mages, S., Cachia, A., Canceil, O., Rodrigo, S., Oppenheim, C., Willard, D., Meder, J.-F., Martinot, J.-L., & Krebs, M.-O. (2007). Sensory dysfunction is correlated to cerebellar volume reduction in early schizophrenia. Schizophrenia Research, 91(1-3), 266-269.


Boddaert, N., Mochel, F., Meresse, I., Seidenwurm, D., Cachia, A., Brunelle, F., Lyonnet, S., & Zilbovicius, M. (2006). Parieto-occipital grey matter abnormalities in children with Williams syndrome. Neuroimage, 30(3), 721-725.


Andoh, J., Artiges, E., Pallier, C., Rivière, D., Mangin, J.-F., Cachia, A., Plaze, M., Paillère-Martinot, M.-L., & Martinot, J.-L. (2005). Modulation of language areas with functional MR image-guided magnetic stimulation. Neuroimage, 29(2), 619-627.

Régis, J., Mangin, J.-F., Ochiai, T., Frouin, V., Rivière, D., Cachia, A. , Tamura, M., & Samson, Y. (2005). Sulcal root generic model: a hypothesis to overcome the variability of the human cortex folding patterns. Neurologia Medico Chirurgica, 45, 1-17.


Mangin, J.-F., Poupon, F., Duchesnay, E., Rivière, D., Cachia, A., Collins, D.L., Evans, A.C., & Régis, J. (2004). Brain Morphometry using 3D Moment Invariants. Medical Image Analysis, 8, 187-196.

Mangin, J.-F., Rivière, D., Cachia, A., Duchesnay, E., Cointepas, Y., Papadopoulos-Orfanos, D., Collins, D.L., Evans, A.C., & Régis, J. (2004). Object-based morphometry of the cerebral cortex. IEEE Transactions on Medical Imaging, 23(8), 968-982.

Mangin, J.-F., Rivière, D., Cachia, A., Duchesnay, E., Cointepas, Y., Papadopoulos-Orfanos, D., Scifo, P., Ochiai, T., Brunelle, F., & Régis, J. (2004). A framework to study the cortical folding patterns. Neuroimage, 23, S129-S138.

Mangin, J.-F., Rivière, D., Coulon, O., Poupon, C., Cachia, A., Cointepas, Y., Poline, J.-B., Le Bihan, D., Régis, J., & Papadopoulos-Orfanos, D. (2004). Coordinate-based versus structural approaches to brain image analysis. Artificial Intelligence in Medicine, 30, 177-197.

Molko, N., Cachia, A., Rivière, D., Mangin, J.-F., Bruandet, M, Le Bihan, D., Cohen, L., & Dehaene, S. (2004). Brain Anatomy in Turner Syndrome: Evidence for Impaired Social and Spatial-Numerical Networks. Cerebral Cortex, 14(8), 840-850.


Cachia, A., Mangin, J.-F., Rivière, D., Kherif, F., Boddaert, N., Andrade, A., Papadopoulos-Orfanos, D., Poline, J.-B., Bloch, I., Zilbovicius, M., Sonigo, P., Brunelle, F., & Régis, J. (2003). A Primal Sketch of the Cortex Mean Curvature: a Morphogenesis Based Approach to Study the Variability of the Folding Patterns. IEEE Transactions on Medical Imaging, 22(6), 754-765.

Cachia, A., Mangin, J.-F., Rivière, D., Papadopoulos-Orfanos, D., Kherif, F., Bloch, I., & Régis, J. (2003). A generic framework for parcellation of the cortical surface into gyri using geodesic Voronoï diagrams. Medical Image Analysis, 7(4), 403-416.

Molko, N., Cachia, A., Rivière, D., Mangin, J.-F., Bruandet, M., Le Bihan, D., Cohen, L., & Dehaene, S. (2003). Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin. Neuron, 40, 847-858.


Jardri, R., Cachia, A., Thomas, P. & Pins, D. (Editors). The Neuroscience of Hallucinations. Springer-Verlag New York Inc. Sept. 2012. web

Jardri, R., Pins, D., Thomas, P., & Cachia, A. Key-issues for future research in the neuroscience of hallucinations. The Neuroscience of hallucinations (Ed. R. Jardri, A. Cachia, D. Pins, P. Thomas). Springer US.

Plaze, M., & Cachia, A. Structural imaging of the ‘hallucinating’ brain in schizophrenia. The Neuroscience of hallucinations (Ed. R. Jardri, A. Cachia, D. Pins, P. Thomas). Springer US.