PubMed: 78 publications

H : 23 (Google Scholar)

Nombre de citations : 5518 (Google Scholar)

SIGAPS: 1545

 

Publications

78. Tavernier Q, Mami I, Rabant M, Karras A, Laurent-Puig P, Chevet E, Thervet E, Anglicheau D, Pallet N. Urinary Angiogenin Reflects the Magnitude of Kidney Injury at the Infrahistologic Level. J Am Soc Nephrol. 2016 Jul 19. pii: ASN.2016020218. [Epub ahead of print]

77. Flahault A, Metzger M, Chassé JF, Haymann JP, Boffa JJ, Flamant M, Vrtovsnik F, Houillier P, Stengel B, Thervet E, Pallet N; NephroTest study group. Low Serum Creatine Kinase Level Predicts Mortality in Patients with a Chronic Kidney Disease. PLoS One. 2016 Jun 1;11(6):e0156433. doi: 10.1371/journal.pone.0156433. eCollection 2016.

76. Fernández-Ramos AA, Poindessous V, Marchetti-Laurent C, Pallet N, Loriot MA. The effect of immunosuppressive molecules on T-cell metabolic reprogramming. Biochimie. 2016 Aug;127:23-36. doi: 10.1016/j.biochi.2016.04.016. Epub 2016 Apr 25. Review.

75. Pallet N, Etienne I, Buchler M, Hurault de Ligny B, Choukroun G, Colosio C, Thierry A, Vigneau C, Moulin B, Le Meur Y, Heng AE, Legendre C, Beaune P, Loriot MA, Thervet E. Long-term clinical impact of adaptation of initial tacrolimus dosing to CYP3A5 genotype. Am J Transplant. 2016 Mar 17. doi: 10.1111/ajt.13788. [Epub ahead of print]

74. Jannot AS, Vuillemin X, Etienne I, Buchler M, Hurault de Ligny B, Choukroun G, Colosio C, Thierry A, Vigneau C, Moulin B, Rerolle JP, Heng AE, Subra JF, Legendre C, Beaune P, Loriot MA, Thervet E, Pallet N. A lack of significant effect of POR*28 allelic variant on tacrolimus exposure in kidney transplant recipients. Ther Drug Monit. 2015 Dec 18.

73. Mami I, Tavernier Q, Bouvier N, Aboukamis R, Desbuissons G, Rabant M, Poindessous V, Laurent-Puig P, Beaune P, Tharaux PL, Thervet E, Chevet E, Anglicheau D, Pallet N. A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney. J Am Soc Nephrol. 2016 Jan 28. pii: ASN.2015060703

72. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J (…) Pallet N (…)Zhou SF, Zhou XJ, Zhu H, Zhu H, Zhu WG, Zhu W, Zhu XF, Zhu Y, Zhuang SM, Zhuang X, Ziparo E, Zois CE, Zoladek T, Zong WX, Zorzano A, Zughaier SM Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222

71. Dieudé M, Bell C, Turgeon J, Beillevaire D, Pomerleau L, Yang B, Hamelin K, Qi S, Pallet N, Béland C, Dhahri W, Cailhier JF, Rousseau M, Duchez AC, Lévesque T, Lau A, Rondeau C, Gingras D, Muruve D, Rivard A, Cardinal H, Perreault C, Desjardins M, Boilard É, Thibault P, Hébert MJ. The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection. Sci Transl Med. 2015 Dec 16;7(318):318ra200. doi: 10.1126/scitranslmed.aac9816

70. Mami I, Pallet N. Transfer RNA fragmentation and protein translation dynamics in the course of kidney injury. RNA Biol. 2015 Oct 29:0.

69. Mami I, Bouvier N, El Karoui K, Gallazzini M, Rabant M, Laurent-Puig P, Li S, Tharaux PL, Beaune P, Thervet E, Chevet E, Hu GF, Pallet N. Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury. J Am Soc Nephrol. 2015 Jul 20. pii: ASN.2015020196.

68. Pallet N, Mami I, Schmitt C, Karim Z, François A, Rabant M, Nochy D, Gouya L, Deybach JC, Xu-Dubois Y, Thervet E, Puy H, Karras A. High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria. Kidney Int. 2015 Aug;88(2):386-95. doi: 10.1038/ki.2015.97.

67. Pallet N, Jannot AS, El Bahri M, Etienne I, Buchler M, de Ligny BH, Choukroun G, Colosio C, Thierry A, Vigneau C, Moulin B, Le Meur Y, Heng AE, Subra JF, Legendre C, Beaune P, Alberti C, Loriot MA, Thervet E. Kidney Transplant Recipients Carrying the CYP3A4*22 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations. Am J Transplant. 2015 Mar;15(3):800-5.

66. Fougeray S, Pallet N. Mechanisms and biological functions of autophagy in diseased and ageing kidneys. Nat Rev Nephrol. 2015 Jan;11(1):34-45.

65. Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, Kwiatkowski DJ, Scoazec JY, Martignoni G, Pende M. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014 Oct 20;211(11):2249-63.

64. Pallet N, Thervet E, Timsit MO. Angiogenic response following renal ischemia reperfusion injury: new players. Prog Urol. 2014 Jun;24 Suppl 1:S20-5.

63. Pallet N, Thervet E, Beaune P, Karras A, Bertho G. The urinary metabolome of chronic kidney disease. Kidney Int. 2014 May;85(5):1239-40.

62. Pallet N. Response letter to "autophagy in renal ischemia-reperfusion injury: friend or foe?". Am J Transplant. 2014 Jun;14(6):1466-7.

61. Martinez F, Pallet N. When erythropoietin meddles in immune affairs. J Am Soc Nephrol. 2014 Sep;25(9):1887-9.

60. Pallet N. Emerging roles of autophagy in the stressed kidney allograft. Semin Nephrol. 2014 Jan;34(1):34-41.

59. Carichon M, Pallet N, Schmitt C, Lefebvre T, Gouya L, Talbi N, Deybach JC, Beaune P, Vasos P, Puy H, Bertho G. Urinary metabolic fingerprint of acute intermittent porphyria analyzed by (1)H NMR spectroscopy. Anal Chem. 2014 Feb18;86(4):2166-74.

58. Pallet N, Chauvet S, Chassé JF, Vincent M, Avillach P, Levi C, Meas-Yedid V, Olivo-Marin JC, Nga-Matsogo D, Beaune P, Thervet E, Karras A. Urinary retinol binding protein is a marker of the extent of interstitial kidney fibrosis. PLoS One. 2014 Jan 8;9(1):e84708. doi: 10.1371/journal.pone.0084708.

57. Pallet N, Livingston M, Dong Z. Emerging functions of autophagy in kidney transplantation. Am J Transplant. 2014 Jan;14(1):13-20. Review.

56. Bertrand D, Pallet N, Sartorius A, Zahar JR, Soussan RS, Lortholary O, Legendre C, Mamzer MF. Clinical and microbial impact of screening kidney allograft preservative solution for bacterial contamination with high-sensitivity methods. Transpl Int. 2013 Aug;26(8):795-9.

55. Bertrand D, Desbuissons G, Pallet N, Sartorius A, Legendre C, Mamzer MF, Sberro Soussan R. Acute renal failure and volume overload syndrome secondary to a femorofemoral arteriovenous fistula angioplasty in a kidney transplant recipient. Case Rep Transplant. 2013;2013:197524.

54. Pallet N, Sirois I, Bell C, Hanafi LA, Hamelin K, Dieudé M, Rondeau C, Thibault P, Desjardins M, Hebert MJ. A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. Proteomics. 2013 Apr;13(7):1108-20.

53. Pallet N, Legendre C. Adverse events associated with mTOR inhibitors. Expert Opin Drug Saf. 2013 Mar;12(2):177-86. Review.

52. Bertrand D, Desbuissons G, Pallet N, Debure A, Sartorius A, Anglicheau D, Mamzer MF, Legendre C, Sberro-Soussan R. Sirolimus therapy may cause cardiac tamponade. Transpl Int. 2013 Feb;26(2):e4-7.

51. Pallet N, Rabant M, Legendre C, Martinez F, Choukroun G. The nephroprotective properties of recombinant human erythropoietin in kidney transplantation: experimental facts and clinical proofs. Am J Transplant. 2012 Dec;12(12):3184-90.

50. Klionsky DJ, Gukovskaya AS, Gukovsky I, Gunst J, Gustafsson AB, Halayko AJ, Hale AN, Halonen SK, Hamasaki M, Han F, Han T, Hancock MK, Hansen M, Harada H, Harada M, Hardt SE, Harper JW, Harris AL, Harris J, Harris SD, Hashimoto M, Haspel JA, Hayashi S, Hazelhurst LA, He C, He YW, Hébert MJ, Heidenreich KA, Helfrich MH, Helgason GV, Henske EP, Herman B, Herman PK, Hetz C, Hilfiker S, Hill JA, Hocking LJ, Hofman P, Hofmann TG, Hahfeld J, Holyoake TL, Hong MH, Hood DA, Hotamisligil GS, Houwerzijl EJ, Høyer-Hansen M, Hu B, Hu CA, Hu HM, Hua Y, Novak I, Nozaki T, Nukina N, Neurnberger T, Nyfeler B, Obara K, Oberley TD, Oddo S, Ogawa M, Ohashi T, Okamoto K, Oleinick NL, Oliver FJ, Olsen LJ, Olsson S, Opota O, Osborne TF, Ostrander GK, Otsu K, Ou JH, Ouimet M, Overholtzer M, Ozpolat B, Paganetti P, Pagnini U, Pallet N, Palmer GE, Palumbo C, Pan T, Panaretakis T, Pandey UB, Papackova Z, Papassideri I, Paris I, Park J, Park OK, Parys JB, Parzych KR, Patschan S, Patterson C, Pattingre S, Pawelek JM, Peng J, Perlmutter DH, Perrotta I, Perry G, Pervaiz S, Peter M, Peters GJ, Petersen M, Petrovski G, Phang JM, Piacentini M, Pierre P, Pierrefite-Carle V, Pierron G, Pinkas-Kramarski R, Piras A, Piri N, Platanias LC, Paggeler S, Poirot M, Poletti A, Poes C, Pozuelo-Rubio M, Pretorius-Ibba M, Prasad A, Prescott M, Priault M, Produit-Zengaffinen N, Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

49. Fougeray S, Mami I, Bertho G, Beaune P, Thervet E, Pallet N. Tryptophan depletion and the kinase GCN2 mediate IFN-γ-induced autophagy. J Immunol. 2012 Sep 15;189(6):2954-64.

48. Sirois I, Groleau J, Pallet N, Brassard N, Hamelin K, Londono I, Pshezhetsky AV, Bendayan M, Hébert MJ. Caspase activation regulates the extracellular export of autophagic vacuoles. Autophagy. 2012 Jun;8(6):927-37.

47. Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z. Emerging role of autophagy in kidney function, diseases and aging. Autophagy. 2012 Jul 1;8(7):1009-31. Review.

46. Pallet N, Dieudé M, Cailhier J, Hébert M. The molecular legacy of apoptosis in transplantation. Am J Transplant. 2012 Jun;12(6):1378-84. Review.

45. Bouvier N, Fougeray S, Beaune P, Thervet E, Pallet N. The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stress. J Biol Chem. 2012 Apr 27;287(18):14557-68.

44. Fournier C, Pallet N, Cherqaoui Z, Pucheu S, Kreis H, Méjean A, Timsit MO, Landais P, Legendre C. Very long-term follow-up of living kidney donors. Transpl Int. 2012 Apr;25(4):385-90.

43. Bererhi L, Pallet N, Zuber J, Anglicheau D, Kreis H, Legendre C, Candon S. Clinical and immunological features of very long-term survivors with a single renal transplant. Transpl Int. 2012 May;25(5):545-54.

42. Pallet N, Thervet E, Desjardins M. Interpreting gene-expression profiles in transplantation: a critical appraisal. Front Genet. 2011 Dec 28;2:98.

41. Pallet N. The presence of autophagy in mammal cells should be interpreted carefully. Am J Transplant. 2012 Apr;12(4):1066.

40. Choukroun G, Kamar N, Dussol B, Etienne I, Cassuto-Viguier E, Toupance O, Glowacki F, Moulin B, Lebranchu Y, Touchard G, Jaureguy M, Pallet N, Le Meur Y, Rostaing L, Martinez F; CAPRIT study Investigators. Correction of postkidney transplant anemia reduces progression of allograft nephropathy. J Am Soc Nephrol. 2012 Feb;23(2):360-8.

39. Fougeray S, Loriot MA, Nicaud V, Legendre C, Thervet E, Pallet N. Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers. Transplant Proc. 2011 Nov;43(9):3418-22.

38. Pallet N, Hébert MJ. The apoptotic program promotes tissue remodeling and fibrosis. Kidney Int. 2011 Nov;80(10):1108;

37. Pallet N, Thervet E, Anglicheau D. c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes. J Transplant. 2012;2012:348604.

36. Pallet N. New insights on stress-induced epithelial phenotypic changes. Nephrol Dial Transplant. 2012 Feb;27(2):483-5.

35. Adam J, Bollée G, Fougeray S, Noêl LH, Antignac C, Knebelman B, Pallet N. Endoplasmic reticulum stress in UMOD-related kidney disease: a human pathologic study. Am J Kidney Dis. 2012 Jan;59(1):117-21.

34. Pallet N, Thervet E. The genetics of kidney transplantation. Hum Genet. 2012 Mar;131(3):317-23.

33. Fougeray S, Bouvier N, Beaune P, Legendre C, Anglicheau D, Thervet E, Pallet N. Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response. Cell Death Dis. 2011 Apr 14;2:e143.

32. Pallet N, Djamali A, Legendre C. Challenges in diagnosing acute calcineurin-inhibitor induced nephrotoxicity: from toxicogenomics to emerging biomarkers. Pharmacol Res. 2011 Jul;64(1):25-30.

31. Jacquet A, Pallet N, Kessler M, Hourmant M, Garrigue V, Rostaing L, Kreis H, Legendre C, Mamzer-Bruneel MF. Outcomes of renal transplantation in patients with autosomal dominant polycystic kidney disease: a nationwide longitudinal study. Transpl Int. 2011 Jun;24(6):582-7.

30. Courbebaisse M, Xu-Dubois YC, Thervet E, Prié D, Zuber J, Kreis H, Legendre C, Rondeau E, Pallet N. Cholecalciferol supplementation does not protect against renal allograft structural and functional deterioration: a retrospective study. Transplantation. 2011 Jan 27;91(2):207-12.

29. Pallet N, Legendre C. Deciphering calcineurin inhibitor nephrotoxicity: a pharmacological approach. Pharmacogenomics. 2010 Oct;11(10):1491-501.

28. Canaud G, Knebelmann B, Harris PC, Vrtovsnik F, Correas JM, Pallet N, Heyer CM, Letavernier E, Bienaimé F, Thervet E, Martinez F, Terzi F, Legendre C. Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level? Am J Transplant. 2010 Jul;10(7):1701-6.

27. Martinez F, Kamar N, Pallet N, Lang P, Durrbach A, Lebranchu Y, Adem A, Barbier S, Cassuto-Viguier E, Glowaki F, Le Meur Y, Rostaing L, Legendre C, Hermine O, Choukroun G; NeoPDGF Study Investigators. High dose epoetin beta in the first weeks following renal transplantation and delayed graft function: Results of the Neo-PDGF Study. Am J Transplant. 2010 Jul;10(7):1695-700.

26. Pallet N, Burgard M, Quamouss O, Rabant M, Bererhi L, Martinez F, Thervet E, Anglicheau D, Noel LH, Rouzioux C, Legendre C. Cidofovir may be deleterious in BK virus-associated nephropathy. Transplantation. 2010 Jun 27;89(12):1542-4.

25. Pallet N, Bouvier N, Beaune P, Legendre C, Anglicheau D, Thervet E. [Involvement of endoplasmic reticulum stress in solid organ transplantation]. Med Sci (Paris). 2010 Apr;26(4):397-403. doi: 10.1051/medsci/2010264397. Review.

24. Snanoudj R, Rabant M, Royal V, Pallet N, Noël LH, Legendre C. [Nephrotoxicity of calcineurin inhibitors: presentation, diagnostic problems and risk factors]. Nephrol Ther. 2009 Dec;5 Suppl 6:S365-70. doi: 10.1016/S1769-7255(09)73427-3.

23. Sberro-Soussan R, Zuber J, Suberbielle-Boissel C, Candon S, Martinez F, Snanoudj R, Rabant M, Pallet N, Nochy D, Anglicheau D, Leruez M, Loupy A, Thervet E, Hermine O, Legendre C. Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies. Am J Transplant. 2010 Mar;10(3):681-6.

22. Legendre Ch, Kreis H, Martinez F, Snanoudj R, Mamzer MF, Sberro R, Bererhi L, Anglicheau D, Zuber J, Loupy A, Thervet E, Pallet N, Sartorius A, Bertrand D, Canaud G, Noël LH, Rabant M, Timsit MO, Méjean A. Kidney transplantation at Necker Hospital: the most recent 5-year period (2004-2009). Clin Transpl. 2010:127-32.

21. Pallet N, Rouach Y, Correas JM, Zahar JR, Legendre C, Mamzer MF. Bilateral urinary leak originating from the native ureters in a dual kidney transplant patient. Transpl Int. 2010 Sep;23(9):e51-2. doi: 10.1111/j.1432-2277.2009.01034.x.

20. Pallet N, Anglicheau D, Thervet E. Autophagy is an adaptative mechanism against endoplasmic reticulum stress. Nephrol Dial Transplant. 2009 Dec;24(12):3891; author reply 3891.

19. Pallet N, Bouvier N, Legendre C, Beaune P, Thervet E, Choukroun G, Martinez F. Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity. Pharmacol Res. 2010 Jan;61(1):71-5.

18. Pallet N, Fougeray S, Beaune P, Legendre C, Thervet E, Anglicheau D. Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation. Transplantation. 2009 Sep 15;88(5):605-13.

17. Pallet N, Loriot MA, Anglicheau D, Legendre C, Beaune P, Thervet E. VKORC1 haplotypes and long-term renal allograft survival. Transplantation. 2009 Mar 27;87(6):942.

16. Pallet N, Anglicheau D. Autophagy: a protective mechanism against nephrotoxicant-induced renal injury. Kidney Int. 2009 Jan;75(1):118-9;

15. Pallet N, Bouvier N, Beaune P, Legendre C, Thervet E, Anglicheau D. [Endoplasmic reticulum stress in kidney diseases: a question of life and death?]. Nephrol Ther. 2009 Jun;5(3):173-80. doi: 10.1016/j.nephro.2008.10.007.

14. Bouvier N, Flinois JP, Gilleron J, Sauvage FL, Legendre C, Beaune P, Thervet E, Anglicheau D, Pallet N. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death. Am J Physiol Renal Physiol. 2009 Jan;296(1):F160-9.

13. Pallet N, Bouvier N, Bendjallabah A, Rabant M, Flinois JP, Hertig A, Legendre C, Beaune P, Thervet E, Anglicheau D. Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death. Am J Transplant. 2008 Nov;8(11):2283-96.

12. Pallet N, Thervet E, Legendre C, Anglicheau D. Sirolimus early graft nephrotoxicity: clinical and experimental data. Curr Drug Saf. 2006 May;1(2):179-87. Review.

11. Pallet N, Bouvier N, Legendre C, Gilleron J, Codogno P, Beaune P, Thervet E, Anglicheau D. Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy. 2008 Aug;4(6):783-91.

10. Hertig A, Anglicheau D, Verine J, Pallet N, Touzot M, Ancel PY, Mesnard L, Brousse N, Baugey E, Glotz D, Legendre C, Rondeau E, Xu-Dubois YC. Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol. 2008 Aug;19(8):1584-91.

9. Pallet N, Rabant M, Xu-Dubois YC, Lecorre D, Mucchielli MH, Imbeaud S, Agier N, Hertig A, Thervet E, Legendre C, Beaune P, Anglicheau D. Response of human renal tubular cells to cyclosporine and sirolimus: a toxicogenomic study. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):184-96.

8. Pallet N, Beaune P, Thervet E, Legendre C, Anglicheau D. [mTOR inhibitors: pleiotropic antiproliferative drugs]. Med Sci (Paris). 2006 Nov;22(11):947-52. Review.

7. Pallet N, Thervet E, Legendre C, Anglicheau D. [Nephrotoxicity of sirolimus: experimental and clinical data]. Nephrol Ther. 2006 Sep;2(4):183-90.

6. Anglicheau D, Pallet N, Rabant M, Marquet P, Cassinat B, Méria P, Beaune P, Legendre C, Thervet E. Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Kidney Int. 2006 Sep;70(6):1019-25.

5. Pallet N, Anglicheau D, Martinez F, Mamzer MF, Legendre C, Thervet E. Comparison of sequential protocol using basiliximab versus antithymocyte globulin with high-dose mycophenolate mofetil in recipients of a kidney graft from an expanded-criteria donor. Transplantation. 2006 Mar 27;81(6):949-52.

4. Pallet N, Beaune P, Legendre C, Anglicheau D. [Rapamycine and mTOR inhibitors: from bench to bedside]. Ann Biol Clin (Paris). 2006 Mar-Apr;64(2):107-15.

3. Pallet N, Thervet E, Alberti C, Emal-Aglaé V, Bedrossian J, Martinez F, Roy C, Legendre C. Kidney transplant in black recipients: are African Europeans different from African Americans? Am J Transplant. 2005 Nov;5(11):2682-7.

2. Pallet N, Thervet E, Le Corre D, Knebelmann B, Nusbaum P, Tomkiewicz C, Meria P, Flinois JP, Beaune P, Legendre C, Anglicheau D. Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability. Kidney Int. 2005 Jun;67(6):2422-33.

1. Pallet N, Aaron L, Larousserie F, Therby A, Dupont B, Viard JP. Kikuchi-Fujimoto disease associated with mixed connective tissue disease. Scand J Rheumatol. 2004;33(6):434-6.