Ouriel CAEN
Ouriel Caën
ouriel.caen<at>parisdescartes.fr
27 years old
French, Israeli
LinkedIn
BIOGRAPHY
Ouriel is a biophysicist who develops new microfluidic technologies to tackle questions related to the emergence of resistance to targeted cancer therapies at the single-cell level. His research involves academic international collaborations (Max Planck Institute, Göttingen, Germany; Bordeaux University, France; EPFL, Switzerland) as well as industrial collaborations (Fluigent, Paris). He is now looking for opportunities in technological transfer.
EDUCATION
2016-
TTO eDIAG platform
2012–2016
Université Sorbonne Paris Cité / FDV International PhD program, Paris, France.
Valérie Taly’s group, PhD student
• Directed evolution to highlight new cancer biomarkers using digital microfluidics
Collaboration with the Group of Jean Christophe Baret, Max Planck Institute of Göttingen (Germany)/ Univ. of Bordeaux (France).
2010-2012
Paris Diderot University, Center for Research and Interdisciplinarity, Paris, France
Master of Science (MSc) in Biophysics
EXPERIENCE IN INDUSTRY
April–September 2012
L'Oréal, L'Oréal Research & Innovation / Department of Advanced Research, Skin Biophysics group, Aulnay-sous-Bois, France
• Modification of Stratum Corneum thermotropic behaviour by cosmetic formulations
June–July 2009
ENEMA Electronics & Mechanics, Jerusalem, Israel
• Maximum Power Point Tracking of photovoltaic systems using extremum-seeking
Control and Matlab-Simulink modeling
July–August 2008
SNCF, French National Railway Corporation, Paris, France
• Commercial officer
EXPERIENCE IN ACADEMY
January - April 2012
ESPCI, Patrick Tabeling’s group, Paris, France
• Droplet-based microfluidics for single neuron analysis to study Parkinson's disease in Drosophila
September - January 2011
Institut Curie, Jean François Joanny’s group, Paris, France
• Mechanical control of cell flow in multicellular spheroids
May - November 2011
Center for Research and Interdisciplinarity, iGEM competition, Paris, France
• “TuBe or not TuBe?” 2011: characterization of a new cell-to-cell bacterial communication system (via nanotubes) using synthetic constructs
June - August 2010
Hebrew University of Jerusalem, Hadassah Medical Center, Assaf Zemel’s group , Jerusalem, Israel
• Dynamics of cell spreading, as a function of the kinetics of the lamellipodium-substrate interaction and the matrix rigidity
TEACHING/MENTORING
October 2015 & 2016
Design and organization of a two day microfluidics laboratory course for B.Sc. students
May-July 2016
Supervision of M.Sc. intern Giorgos Pavlou (Interdisciplinary Approaches to Life Science (AIV) Master Program (M2))
February-June 2016
Supervision of M.Sc. intern M.S.S. Jammalamadaka. (Interdisciplinary Approaches to Life Science (AIV) Master Program Student (M1))
June-July 2014
Co-Supervision of bachelor intern Siddhansh Agarwal. Mechanical Engineering at Birla Institute of Technology & Science (BITS),Pilani, India.
Today PhD student at University of Illinois Urbana-Champaign, USA.
March-May 2013
Supervision of master intern Aishah Prastowo (Interdisciplinary Approaches to Life Science (AIV) Master 2013 Program Student (M2)).
Today PhD student at Department of Engineering Science, University of Oxford, Oxford, UK.
AWARDS
2015
ARC foundation, France
• 1 years PhD fellowship
2012
French National Cancer Institute, France
• 3 years full PhD fellowship
2011
MIT's International Genetically Engineered Machines competition (iGEM), Boston, USA
• First runner-up of European Championship, Best Presentation Prize
PUBLICATIONS
2016
Accurate high-throughput cell counting using droplet-based microfluidics. H. Lu#, O. Caen#, J. Vrignon, P. Nizard, J-C. Baret, V. Taly. Scientific reports. In press. #Co-first name.
Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations. Zonta E, Garlan F, Pécuchet N, Perez-Toralla K, Caen O, Milbury C, Didelot A, Fabre E, Blons H, Laurent-Puig P, Taly V. PLoS One. 2016 Jul 14;11(7):e0159094.
2015
Parallelized ultra-high throughput microfluidic emulsifier for multiplex kinetic assays. Lim J, Caen O, Vrignon J, Konrad M, Taly V, Baret JC. Biomicrofluidics. 9(3):034101.
2014
Pipette-and-play: parallelized ultra-high throughput microfluidic emulsifier for quantitative biochemical assays. J. Lim, O. Caen, J. Vrignon, M. Konrad, V. Taly and J.C. Baret.
In: Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), p. 258-260. ISBN: 978-0-9798064-7-6.
[Digital PCR compartmentalization II. Contribution for the quantitative detection of circulating tumor DNA]. Caen, O., Nizard, P., Garrigou, S., Perez-Toralla, K., Zonta, E., Laurent-Puig, P. and Taly, V.* Medecine/Sciences. 31(2):180-6.
2013
Mechanical Control of Cell flow in Multicellular Spheroids. Morgan Delarue, Fabien Montel, Ouriel Caen, Jens Elgeti, Jean-Michel Siaugue, Danijela Vignjevic, Jacques Prost, Jean-François Joanny, and Giovanni Cappello. Phys. Rev. Lett. 110, 138103
ORAL COMMUNICATIONS (peer reviewed scientific conferences)
Assessing cancer drug resistance at the single-cell level. NanoBiotech Montreux, Montreux (2016).
Pipette & play microfluidics: towards simple parallelization. IFP Energies nouvelles, Paris (2015).
Pipette-and-play: parallelized ultra-high throughput microfluidic emulsifier for quantitative biochemical assays. Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), San Antonio, Texas (2014).
Pipette-and-play: parallelized ultra-high throughput microfluidic emulsifier for quantitative biochemical assays. GDR Micro Nano Systems-Micro Nano Fluidic. Ecole Polytechnique, Palaiseau - France. (2014).
ORAL COMMUNICATIONS (academic & industrial workshops)
Pipette & play microfluidics: towards simple parallelization. IFP Energies nouvelles, Paris. November 5th 2015.
Pipette & Play microfluidics. Towards simple parallelization. Fluigent workshop on microfluidics, Fluigent Headquarters, Villejuif, France. July 9th 2014.
Microfluidics, Cancer and Directed Evolution. Seminar. Interdisciplinary Fridays, Center for Research and Interdisciplinarity, Paris. France. June 14h 2013.
LANGUAGES
French (Native), Hebrew (Native), English (Full professional proficiency), Arabic (Elementary proficiency)
CONTACTS
- Prof. Valérie Taly. valerie.taly@parisdescartes.fr. 01 70 64 99 73.
- Prof. Jean-Christophe Baret. jean-christophe.baret@u-bordeaux.fr. 05 56 84 56 34.
- Dr. Yegor Domanov. YDOMANOV@rd.loreal.com. 01 58 31 73 28.